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Extracellular Fluids

Fri, 12/21/2007 - 12:07 — oxygen
EXTRACELLULAR FLUID Listen to Audio Fluids1.jpg -composed of intravascular compartment and interstitial compartment -Na+ is the most important determinant for the extracellular osmotic pressure and volume -changes in total body sodium content generally reflects the extracellular volume Extracellular fluid provides a medium for: -cellular nutrients and electrolyes -cellular waste products Interstitial fluid Generally associated with: -extracellular proteoglycans which forms a gel -negative pressure  -5mmHg -edema is generally associated with a positive interstitial fluid pressure Intravascular fluid -small electrolytes are able to pass freely from interstitium into the intravascular space -identical electrolyte composition between the plasma intravascular space and interstitium -plasma proteins (albumin) are the only osmotically active solute in the plasma that is not exchanged w.in the interstitial fluid clinical example: tissue edema -occurs with increased extracellular fluid volume -interstitial pressure becomes positive -additional increases in extracellular fluid expands the interstitial compartment -resultant tissue edema

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