Intracellular Fluid |

Intracellular Fluid

Fri, 12/21/2007 - 12:04 — oxygen

Intracellular Fluid Listen to Audio

-K+ is the most important determinant of intracellular osmotic pressure -Na+ is the most important determinant of extracellular osmotic pressure -due to impermeable cell membranes the intracellular compartment contains high intracellular protein concentration -Na+/K+ ATPase prevents intracellular hyperosmolality Clinical example: during ischemia/hypoxia: -leads to interruption of Na+/K+ ATPase -creates progressive cellular swelling due to the resultant hyperosmolality -eventual cell damage ex. cerebral edema

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