Anesthesia

Pharmacodynamics - Inhalational Anesthetics

Your Ad Here PHARMACODYNAMICS Listen to Audio THEORIES OF ANESTHETIC ACTION -unitary hypothesis -critical volume hypothesis -fluid theory of anesthesia -lateral phase separation theory MINIMUM ALVEOLAR CONCENTRATION (MAC) -minimum alveolar concentration of an inhaled anesthetic which prevents movement in 50% of patients in response surgical incision -mirrors brain partial pressures -allows for comparison of potency amongst differing anesthetic agents -provides a standard for expiremental observations MAC (awake): 0.3 MAC MAC (amnesia): 0.5 MAC MAC:(ED 50): 1.0 MAC MAC (ED 95): 1.3 MAC MAC (BAR): 1.5 MAC MAC (BAR)= blockade of adrenergic response

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