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Afterload Listen to Audio cardiobody_2.jpg General Factors affecting intraventricular pressure Systemic Vascular Resistance Pulmonary Vascular Resistance General -ventricular wall tension during systole -arterial impedance to ejection wall tension = pressure the ventricle must overcome in order to reduce the ventricular cavity LaPlace’s Law = helps describe wall tension = (intraventricular pressure)(ventricular radius)/ 2 (wall tension) increased wall tension: larger ventricular radius ex. dilated left ventricle decreased wall tension: increased wall thickness ex. left ventricular hypertrophy Factors affecting intraventricular pressure -force of ventricular contraction -viscoelastic properties of aortal proximal branches -viscosity and density of blood -systemic vascular resistance Systemic Vascular Resistance -clinical equivalent of the left ventricular afterload -primarily determined by the arterial tone SVR = [(MAP – CVP)/ CO] x 80 SVRI= SVR x BSA normal SVR: 900 – 1500 dynes-sec-cm-5 Pulmonary Vascular Resistance PVR = [(PAP – LAP)/CO] x 80 normal PVR: 50 – 150 dynes-sec-cm-5

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